Amber up
Kill Sissyface
"Mass non-ruby kill" gears/acroliths/oliphants/bombs for Sys frags/IC/Dhorme pops
Kill Kogahtu
Kill IC
Kill Opas-Kamuhi
Kill Dhorme
Kill Apadmak
Work on souls/upgrades when you happen to find em.
or stock up on Cores/Frags from the AH and speed it up (if its even possible at this point in the game)
repeat 40 times
About 8-10 hours to do it, more if you're new/lack atma/TH