TBFP playing a new game (a bit megaman a bit castlevania) and it has a second form boss that you have to attack it's cleavage for damage and jiggles, oh lordy lol.
At SGDQ 2016, a speed runner known as HalfCoordinated ran this using one hand. He has an issue that causes one side of his body to be less organized so he plays everything one-handed.
His comment on Lubella was "Everyone seems to like this next boss... we're not really sure why."
EDIT: Game is
Momodora
EDIT2: More specifically, HCO ran this not only with one hand but on the hardest difficulty where you die if you get hit once. Iirc